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Downregulates cox-2 · downregulates expression of inflammatory cytokines · reduces the activity of the immune system · alters the. Hydrocortisone is the clinical name for cortisol. There are numerous corticosteroid agents that have been developed for topical use (eg, creams,. Mechanism of action: an adrenocortical steroid that inhibits accumulation of inflammatory cells at inflammation sites, phagocytosis, lysosomal enzyme. Hydrocortisone binds to the cytosolic glucocorticoid receptor. After binding the receptor the newly formed receptor-ligand complex translocates. Mechanism : hydrocortisone is an anti-inflammatory adrenocortical steroid. Indication : · contraindications : hypersensitivity to drug/class/component · dosing :. Hydrocortisone binds to the glucocorticoid receptor leading to downstream effects such as inhibition of phospholipase a2, nf-kappa b, other inflammatory. Half-life elimination: im: 2. 5 hours (hahner 2013); iv: 2 ± ۰٫ ۳ hours; oral: 1. 5 hours (czock 2005); subq: 4. 7 hours (hahner 2013). Hydrocortisone is a steroid (corticosteroid) medicine. It works by calming down your body’s immune response to reduce pain, itching and swelling. That is, it is an agonist of the glucocorticoid and mineralocorticoid receptors

 

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